Calcium carbonate + colecalciferol + menaquinone k7: Should be taken with food.
Colecalciferol: May be taken with or without food. Take w/ meals for better absorption. Avoid taking w/ large amount of fibre-rich food.
Administration
Calcium carbonate + colecalciferol + menaquinone k7: Should be taken with food.
Colecalciferol: May be taken with or without food. Take w/ meals for better absorption. Avoid taking w/ large amount of fibre-rich food. |
Contraindications
Hypercalcaemia resulting from myeloma, bone metastases or other malignant bone disease, sarcoidosis, primary hyperparathyroidism, vitamin D overdosage. Osteoporosis due to long term immobilisation, severe hypercalciuria, kidney stones. Severe renal failure untreated by renal dialysis.
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Special Precautions
Patient with achlorhydria, hypoparathyroid disease; history of kidney stones. Renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor serum and urinary Ca levels, and kidney function in long term treatment.
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Adverse Reactions
Significant: Constipation, bloating, gas, hypercalcaemia.
Endocrine disorders: Hypophosphataemia, milk-alkali syndrome.
Gastrointestinal disorders: Abdominal pain, diarrhoea, hyperacidity (acid rebound), nausea, vomiting, xerostomia.
Metabolism and nutrition disorders: Anorexia.
Nervous system disorders: Headache.
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Drug Interactions
Increased risk of hypercalcaemia with thiazide diuretics. May enhance the effect of cardiac glycosides (e.g. digoxin). May reduce the absorption of thyroxine, bisphosphonates, Na fluoride, antibiotics (quinolone, tetracycline), and Fe. Systemic corticosteroids may reduce Ca absorption.
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ATC Classification
A12AA04 - calcium carbonate ; Belongs to the class of calcium-containing preparations. Used as dietary supplements.
A02AC01 - calcium carbonate ; Belongs to the class of calcium-containing antacids. |